RABBIT ANTI-HISTONE H3 ANTIBODY

Code: PLA0148-100UL D2-231

Biochem/physiol Actions

Histone proteins are the basic building blocks of chromatin. Histone H3 controls protein-protein interactions to induce binding of trans-acting factor...


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€484.00 100UL
€595.32 inc. VAT

Biochem/physiol Actions

Histone proteins are the basic building blocks of chromatin. Histone H3 controls protein-protein interactions to induce binding of trans-acting factors that have a role in chromatin condensation. Histone H3 K27M mutations are observed in adult cerebellar high-grade gliomas.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mammals contain variants of histone H3, that are, the replicative histones (H3.1 and H3.2) and the replacement histones (H3.3). Histone H3 is located on human chromosome 6p22.

Immunogen

The epitope recognized by PLA0148 maps to a region between residue 100 and the C-terminus (residue 135) of human Histone H3 using the numbering given in entry NP_003520.1 (GeneID 8350).

Other Notes

Histone H3 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Physical form

Tris-buffered Saline containing 0.1% BSA with 0.09% Sodium Azide

accession no.NP_003520.1
antibody formaffinity purified immunoglobulin
antibody product typeprimary antibodies
biological sourcerabbit
Gene Informationrabbit ... Histone H3(8350)
gradePowered by Bethyl Laboratories, Inc.
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunoprecipitation (IP): 2-10 µg/mg, immunohistochemistry: 1:200-1:1,000, western blot: 1:2,000- 1:10,000
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